# stemedb-ontology

Domain Ontology Layer for Episteme - defines how subjects are structured based on predicate type and domain. Ensures conflicts collide correctly when different sources report on the same thing.

## Module Overview

| Module | Purpose |
|--------|---------|
| `domain.rs` | Domain, EntityType, PredicateSchema, SourceTier builders |
| `subject.rs` | SubjectBuilder for canonical subject construction |
| `validator.rs` | Validates assertions against domain rules |
| `client.rs` | HTTP client for StemeDB API |
| `dto/` | Request/response DTOs for API communication |
| `pharma/` | Pharmaceutical domain (reference implementation) |

## Quick Start

### CLI Usage (steme-pharma)

```bash
# Build the CLI
cargo build --release -p stemedb-ontology

# Ingest FDA label data
./target/release/steme-pharma ingest semaglutide,tirzepatide

# Ingest with mock conflicts for testing
./target/release/steme-pharma ingest semaglutide --with-conflicts

# Query conflicts (Skeptic lens - default)
./target/release/steme-pharma query "Semaglutide:Type2Diabetes" hba1c_reduction_percent

# Query with source hierarchy (Layered Consensus)
./target/release/steme-pharma query "Semaglutide:Type2Diabetes" weight_loss_percent --mode layered

# Compare two drugs
./target/release/steme-pharma compare \
    "Semaglutide:Type2Diabetes" \
    "Tirzepatide:Type2Diabetes" \
    --predicate hba1c_reduction_percent

# Explore available predicates for a subject
./target/release/steme-pharma explore "Semaglutide:Type2Diabetes"

# Validate a subject/predicate combination
./target/release/steme-pharma validate "Semaglutide:Type2Diabetes" hba1c_reduction_percent

# JSON output (for scripting)
./target/release/steme-pharma --format json query "Semaglutide" nausea_rate
```

### Programmatic Usage

```rust
use stemedb_ontology::{pharma, SubjectBuilder, Validator};
use stemedb_ontology::client::StemeClient;
use stemedb_ontology::pharma::extractors::{FdaLabelExtractor, MedicalExtractor, SourceInput};
use ed25519_dalek::SigningKey;
use rand::rngs::OsRng;

// Load the pharma domain definition
let domain = pharma::definition();

// Build a subject using the ontology
let schema = domain.get_schema("efficacy").unwrap();
let mut entities = std::collections::HashMap::new();
entities.insert("Drug".to_string(), "Semaglutide".to_string());
entities.insert("Indication".to_string(), "Type2Diabetes".to_string());
let subject = SubjectBuilder::build(schema, &entities, &domain).unwrap();
assert_eq!(subject, "Semaglutide:Type2Diabetes");

// Validate assertions
let validator = Validator::new(&domain);
let result = validator.validate("hba1c_reduction_percent", &subject, 0.95);
assert!(result.is_ok());

// Extract and ingest claims
let client = StemeClient::new("http://localhost:18180");
let extractor = FdaLabelExtractor::new();
let signing_key = SigningKey::generate(&mut OsRng);
let agent_id = signing_key.verifying_key().to_bytes();
let hlc = uhlc::HLCBuilder::new().build();

let claims = extractor.extract(&SourceInput::DrugName("semaglutide".into())).await?;
for claim in claims {
    let assertion = claim.to_assertion(&signing_key, agent_id, &hlc);
    let hash = client.assert(&assertion).await?;
    println!("Ingested: {}", hash);
}

// Query for conflicts
let skeptic = client.skeptic("Semaglutide:Type2Diabetes", "hba1c_reduction_percent").await?;
println!("Conflict score: {}", skeptic.conflict_score);
```

## Architecture

```
                  ┌─────────────────────────────────────┐
                  │           Domain Definition         │
                  │  (EntityTypes, Schemas, Hierarchy)  │
                  └──────────────┬──────────────────────┘
                                 │
         ┌───────────────────────┼───────────────────────┐
         │                       │                       │
         v                       v                       v
┌─────────────────┐   ┌──────────────────┐   ┌──────────────────┐
│  SubjectBuilder │   │    Validator     │   │  MedicalExtractor│
│                 │   │                  │   │    (trait)       │
│ Build canonical │   │ Validate against │   │ Extract claims   │
│ subject strings │   │ domain rules     │   │ from sources     │
└────────┬────────┘   └────────┬─────────┘   └────────┬─────────┘
         │                     │                      │
         └──────────────┬──────┴──────────────────────┘
                        │
                        v
              ┌───────────────────┐
              │    StemeClient    │
              │                   │
              │ Submit assertions │
              │ Query with lenses │
              └─────────┬─────────┘
                        │
                        v
              ┌───────────────────┐
              │    StemeDB API    │
              │  :18180/v1/*      │
              └───────────────────┘
```

## Subject Patterns

Different predicate types use different subject structures to ensure proper collision:

| Category | Pattern | Example | Use Case |
|----------|---------|---------|----------|
| Efficacy | `{Drug}:{Indication}` | `Semaglutide:Type2Diabetes` | Outcome measures for specific conditions |
| Safety | `{Drug}` | `Semaglutide` | Adverse events (apply across indications) |
| Mechanism | `{Drug}:{Target}` | `Semaglutide:GLP1R` | Pharmacology details |
| Comparison | `{Drug}:{Comparator}:{Indication}` | `Semaglutide:Tirzepatide:Type2Diabetes` | Head-to-head trials |

## Source Hierarchy

Claims are weighted by source authority:

| Tier | Source Class | Weight | Examples |
|------|--------------|--------|----------|
| 0 | Regulatory | 1.0 | FDA Labels, EMA Reports |
| 1 | Clinical | 0.9 | Phase III RCTs, Lancet, NEJM |
| 2 | Observational | 0.7 | Real-World Evidence, FAERS |
| 3 | Expert | 0.5 | Guidelines, ADA Standards |
| 4 | Community | 0.3 | PatientsLikeMe, Moderated Forums |
| 5 | Anecdotal | 0.1 | Reddit, Twitter, Blog Posts |

## Adding a New Domain

See [Adding a Domain Guide](../../docs/guides/adding-a-domain.md) for step-by-step instructions on implementing new domains (e.g., cardiology, finance).

## Testing

```bash
# Run all ontology tests
cargo test -p stemedb-ontology

# Run with output
cargo test -p stemedb-ontology -- --nocapture

# Consumer Health UAT
cargo test -p stemedb-ontology --test consumer_health_uat
```

## Related Documentation

- [What is Episteme](../../what-is-episteme.md)
- [Architecture](../../architecture.md)
- [Vision](../../vision.md)
- [Consumer Health Use Case](../../docs/app-concepts/consumer-health.md)