b3e8a9a058
Major additions: - Community Next.js app (port 18187) for browsing claims with API docs - stemedb-chaos crate: Fault injection, chaos testing, CRDT properties - Latent ingestion system: Reddit/FDA ingesters with ADK-Go agents - Disputed claims handling: Manual review workflows and validation - Aphoria security scanner: New extractors (SQL injection, command injection, weak crypto, TLS version), policy-based ignores, UAT reports - Docker infrastructure: Dockerfile, docker-compose.yml for full stack - VulnBank demo: Intentionally vulnerable multi-language test corpus SDK & API enhancements: - Source registry handlers for tracking data provenance - Metrics endpoint - Skeptic filtering improvements Code quality: - Split 14 large files (>500 lines) into focused modules - All files now under 500-line limit per project guidelines Documentation: - Chaos testing guide, circuit breakers, observability docs - Phase 7 UAT documentation updates - Martin Kleppmann technical writer agent Co-Authored-By: Claude Opus 4.5 <noreply@anthropic.com>
137 lines
8.3 KiB
Markdown
137 lines
8.3 KiB
Markdown
# Latent: User Interface (ASCII)
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> **Role:** Pharmacovigilance Analyst / BioTech Investor
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> **Task:** Investigating a potential safety signal for "Semaglutide"
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## 1. The Dashboard (The "Heatmap")
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The entry point. Not a search bar, but a live monitor of **Epistemic Divergence**.
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```text
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┌─────────────────────────────────────────────────────────────────────────────────┐
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│ LATENT v1.0 [ Settings ] [ Alerts ] [ Export ] │
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└─────────────────────────────────────────────────────────────────────────────────┘
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WATCHLIST (12 Molecules) DIVERGENCE SCORE (Last 30d)
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─────────────────────────────────────────────────────────────────────────────────
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1. Semaglutide (Ozempic) [CRITICAL] ██████████████░░ 0.88 (+0.12) ▲
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2. Tirzepatide (Mounjaro) [ELEVATED] ████████░░░░░░░░ 0.52 (+0.04) ▲
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3. Risankizumab [STABLE] ██░░░░░░░░░░░░░░ 0.15 (-0.01) ▼
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4. L-Theanine (Supp) [NOISY] ████░░░░░░░░░░░░ 0.28 (+0.00) ─
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─────────────────────────────────────────────────────────────────────────────────
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[ ALERT ] Semaglutide: "Gastroparesis" signal crossed Tier 4 threshold (0.6).
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Primary Driver: Patient Forums (Tier 5) vs Clinical Label (Tier 0).
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```
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## 2. The Molecule View (The "Conflict Engine")
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User clicks "Semaglutide". This is the core view. It splits reality into three layers.
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```text
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┌─────────────────────────────────────────────────────────────────────────────────┐
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│ MOLECULE: Semaglutide │
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│ STATUS: DIVERGENT ⚠️ │
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└─────────────────────────────────────────────────────────────────────────────────┘
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[ LAYER 1: THE OFFICIAL TRUTH (Tier 0-1) ]
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────────────────────────────────────────────────────────────────────────
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FDA Label (2023-01): "GI adverse events common. No mention of paralysis."
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NEJM Trial (Step 1): "Nausea (44%), Vomiting (24%). Transient."
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EMA Filing: "Thyroid signal monitored. No GI alarm."
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────────────────────────────────────────────────────────────────────────
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▼
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▼ (Conflict: 0.88)
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▼
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[ LAYER 2: THE LATENT SIGNAL (Tier 4-5) ]
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────────────────────────────────────────────────────────────────────────
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Reddit (/r/Ozempic): "Stomach paralysis" (Cluster: 412 posts, +45% WoW)
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Twitter (MDs): "Seeing ER admits for aspiration pneumonia." (12 sigs)
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FAERS (Raw): "Gastric obstruction" (84 unverified reports)
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────────────────────────────────────────────────────────────────────────
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[ ANALYSIS: THE SKEPTIC LENS ]
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"The Official Truth says GI issues are 'Transient'.
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The Latent Signal says GI issues are 'Permanent/Severe' (Paralysis).
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This is a CATEGORICAL CONFLICT.
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Signal Authority: Low (Tier 5) but Density is High (Vol > 400)."
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```
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## 3. The Timeline (The "Time Travel")
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User investigates *when* this divergence started.
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```text
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TIMELINE: "Gastroparesis" Signal vs. Label Updates
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──────────────────────────────────────────────────────────────────────────────
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2022-Q1 | 2022-Q2 | 2022-Q3 | 2022-Q4 | 2023-Q1 | 2023-Q2 | 2023-Q3 (Now)
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─────────┼──────────┼──────────┼──────────┼──────────┼──────────┼──────────────
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Label | | | | | |
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(Tier 0) | [SILENT] | [SILENT] | [SILENT] | [SILENT] | [SILENT] | [SILENT]
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─────────┼──────────┼──────────┼──────────┼──────────┼──────────┼──────────────
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Social | | | | | ⚠️ | 🔥
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(Tier 5) | . | .. | ... | ..... | [SIGNAL] | [SURGE]
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| | | | | First | CNN picks
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| | | | | Cluster | up story
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──────────────────────────────────────────────────────────────────────────────
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[ INSIGHT ]
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The Latent Signal emerged in 2023-Q2. The Label is lagging by ~6 months.
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Predicted Label Update: Q4 2023 (Probability: 75%)
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```
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## 4. The Source Inspector (The "Evidence")
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User clicks on the "Reddit Cluster" to see the raw data.
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```text
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┌─────────────────────────────────────────────────────────────────────────────────┐
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│ SOURCE INSPECTOR: Cluster #8492 "Gastroparesis" │
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└─────────────────────────────────────────────────────────────────────────────────┘
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SOURCE CLASS: Tier 5 (Anecdotal/Unverified)
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VOLUME: 412 Assertions
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SENTIMENT: Negative (-0.9)
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[ KEY EXCERPTS ]
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1. "ER Doc said my stomach essentially stopped working. Been off Oz for 3mo."
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(Source: Reddit, Karma: 4k, Date: 2 days ago)
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2. "Diagnosed with gastroparesis after 6 months on 1mg."
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(Source: PatientsLikeMe, Verified User, Date: 1 week ago)
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[ RELATED CLINICAL CONTEXT ]
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* Does this match Mechanism of Action? YES (GLP-1 slows gastric emptying).
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* Is it in the Label? NO (Label says "nausea", not "paralysis").
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```
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## 5. The Command Line (The "Power User")
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For the analyst who wants to query the graph directly.
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```text
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> latent query --subject "Semaglutide" --predicate "side_effect" --lens skeptic
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[RESULT]
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Subject: Semaglutide
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Predicate: side_effect
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1. Nausea (Confidence: 0.99) [Consensus]
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- Sources: FDA, EMA, NEJM, Reddit
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2. Vomiting (Confidence: 0.98) [Consensus]
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- Sources: FDA, EMA, Reddit
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3. Gastroparesis (Confidence: 0.45) [CONFLICT]
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- Sources: Reddit (High Vol), Twitter (Med Vol)
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- Contradicted By: NEJM ("No signal")
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- Source Tier Spread: 4 (Tier 1 vs Tier 5)
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> latent simulate --event "FDA Warning Added"
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[SIMULATION]
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If FDA adds "Gastroparesis" warning (Tier 0):
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- Conflict Score drops to 0.1 (Resolution reached).
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- Liability risk for past prescriptions increases (Knowledge date: 2023-Q2).
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```
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